Trinnpris angis for ikke-patenterte legemidler, hvor det foreligger generisk konkurranse mellom legemidler som Direktoratet for medisinske produkter har vurdert som likeverdige.
Ferraro L, Antonelli T, et al. The vigilance advertising drug modafinil increases extracellular glutamate levels during the medial preoptic place along with the posterior hypothalamus in the aware rat: avoidance by community GABA A receptor blockade.
Observe Intently (one)istradefylline will raise the degree or effect of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
mitotane decreases levels of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Mitotane is a powerful inducer of cytochrome P-4503A4; keep an eye on when coadministered with CYP3A4 substrates for doable dosage adjustments.
Chest Ache. Modafinil can result in chest discomfort, which can be a symptom of a coronary heart assault. The risk of upper body soreness may be higher When you've got a coronary heart ailment named mitral valve prolapse or left ventricular hypertrophy (thick coronary heart partitions about the remaining aspect within your coronary heart).
In the event you’re interested in working with modafinil for maximizing your cognitive capabilities and minimizing tiredness and sleepiness for restricted durations but don’t choose to operate the hazards related to purchasing from international pharmacies, you may want to contemplate its precursor, adrafinil.
Keep away from or substitute A further drug for these remedies when feasible. get more info Evaluate for loss of therapeutic result if medication has to be coadministered. Regulate dose As outlined by prescribing facts if needed.
modafinil will lower the extent or result of copyright topical by influencing hepatic enzyme CYP2B6 metabolism. Small/Importance Unknown.
Modafinil er virkestoffet som finnes i det registrerte legemiddelet Modiodal. Modiodal tilhører gruppen sympatomimetikum. Virkningsmekanismen er tross forskning ikke avklart og er noe usikker.
Your Health care company may possibly keep an eye on you carefully For those who have had a new heart attack or have chest ache linked to little if any activity. Cease taking modafinil and obtain crisis assist without delay.
Ferraro et al (1996) in the main of the number of papers about modafinil’s actions confirmed applying in vivo microdialysis in rats that modafinil decreases GABA in the medial preoptic space in the hypothalamus and the posterior hypothalamus.
Warfarin's considerably less potent R-enantiomer is metabolized partially by CYP3A4 (as well as CYP1A2 and CYP2C19). Monitor INR far more regularly if coadministered with inhibitors of those isoenzymes and regulate warfarin dose if essential.
Medisinen ble opprinnelig utviklet i Frankrike til bruk i det franske forsvaret. Den skulle brukes av det franske flyvåpenets soldater, slik at de skulle føle mindre tretthet og klare å konsentrere seg bedre om oppgavene sine.
Dette legemidlet er skrevet ut kun til deg. Ikke gi det videre til andre. Det kan skade dem, selv om de har symptomer på sykdom som ligner dine.